Catalogue / SNAP-8
SNAP-8
Also written as Acetyl octapeptide-3, Acetyl glutamyl heptapeptide-3.
An eight residue acetylated and amidated cosmetic active, extending the Argireline hexapeptide by two residues.
| Molecular formula | C42H72N16O15S |
| Average mass | 1073.18 Da |
| Monoisotopic mass | 1072.5084 Da |
| Written as | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| Class | Cosmetic active peptides |
| Determination | Peptide analysis, catalogue compound |
| Price | 341 USD |
Computed at build time from the composition shown on this page, not transcribed from a supplier datasheet.
SNAP-8 has an average molecular weight of 1073.18 daltons and a monoisotopic mass of 1072.5084 daltons. Identity is confirmed by matching the measured deconvoluted mass to that figure, and purity is reported separately by reversed-phase chromatography at 214 nm. The two numbers answer different questions and neither substitutes for the other.
| Written sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| Molecular formula | C42H72N16O15S |
This compound contains residues outside the standard twenty, so a theoretical mass cannot be derived from a one-letter sequence. The masses above are computed from the molecular formula instead.
This is not a technicality. A laboratory that computes an expected mass from a sequence lookup will get the wrong number for this compound, and will then either report a false mismatch or adjust the expectation to fit the measurement.
| Charge | m/z |
|---|---|
| [M+1H]+ | 1073.516 |
| [M+2H]2+ | 537.261 |
These are the ions an electrospray source is expected to produce for a neutral mass of 1072.5084 daltons, computed from the monoisotopic mass and the proton mass. They are what a raw spectrum should show before deconvolution.
A report that gives only a deconvoluted mass without the charge states it was derived from cannot be checked. Deconvolution is a calculation, and a calculation whose inputs are not shown is an assertion.
| SNAP-8 and Argireline share their first six residues. SNAP-8 is roughly 185 daltons heavier and is sold at a higher price, which makes the pair worth resolving by mass rather than by label. |
| Supplied as a dilute aqueous solution, commonly at 0.05 percent active. A certificate reporting the solution concentration as the peptide purity is comparing two different quantities. |
| The methionine oxidises, and in a finished emulsion the preservative system co-elutes in the same region as the oxidised form. |
Every compound fails in its own way. A generic peptide method applied without regard to these specifics produces a number that looks like a result and is not one.
Supplied as raw actives or already formulated into an emulsion. In a finished cosmetic the matrix, not the peptide, decides whether the determination works.
LC-MS or HPLC-UV against a certified reference standard with matrix-matched calibration and spike recovery, because emulsifiers and pigments co-extract and suppress ionisation.
Where the delivered milligram figure matters rather than the percentage, net peptide content by combustion analysis and water by Karl Fischer are added, and the certificate carries a closed mass balance instead of a single purity number.
| LC-MS identity | Measured mass |
| RP-HPLC purity | Area at 214 nm |
| Net peptide content | Milligrams |
| Water content | Karl Fischer |
| Counter-ion | Ion chromatography |
| Bacterial endotoxins | USP <85> |
What is the molecular weight of SNAP-8?
The average molecular weight is 1073.18 daltons and the monoisotopic mass is 1072.5084 daltons, computed from the molecular formula C42H72N16O15S shown on this page. Both figures are calculated rather than transcribed, so they can be checked against the stated composition.
How is SNAP-8 tested for purity and identity?
LC-MS or HPLC-UV against a certified reference standard with matrix-matched calibration and spike recovery, because emulsifiers and pigments co-extract and suppress ionisation. Purity describes the chromatographable fraction only and is not the same quantity as the peptide mass delivered per vial.
What goes wrong when SNAP-8 is analysed?
SNAP-8 and Argireline share their first six residues. SNAP-8 is roughly 185 daltons heavier and is sold at a higher price, which makes the pair worth resolving by mass rather than by label.
What does SNAP-8 analysis cost at ANALYTON?
Peptide analysis, catalogue compound is priced at 341 US dollars, covering the determinations described on this page. Content, safety and elemental determinations are ordered alongside and are priced separately on the price list.
Other compounds in this class
Updated 2026-09-01. Masses computed at build, not transcribed.