Catalogue / Liraglutide
Liraglutide
Also written as GLP-1 analogue.
A GLP-1 analogue carrying a palmitoyl chain through a glutamate spacer on lysine 26, and the shortest-acting of the commonly submitted incretins.
| Molecular formula | C172H265N43O51 |
| Average mass | 3751.2 Da |
| Monoisotopic mass | 3748.9465 Da |
| Class | Incretin analogues |
| Determination | Blind identification, GLP-1 class |
| Price | 468 USD |
Computed at build time from the composition shown on this page, not transcribed from a supplier datasheet.
Liraglutide has an average molecular weight of 3751.2 daltons and a monoisotopic mass of 3748.9465 daltons. Identity is confirmed by matching the measured deconvoluted mass to that figure, and purity is reported separately by reversed-phase chromatography at 214 nm. The two numbers answer different questions and neither substitutes for the other.
| Charge | m/z |
|---|---|
| [M+3H]3+ | 1250.656 |
| [M+4H]4+ | 938.244 |
| [M+5H]5+ | 750.797 |
These are the ions an electrospray source is expected to produce for a neutral mass of 3748.9465 daltons, computed from the monoisotopic mass and the proton mass. They are what a raw spectrum should show before deconvolution.
A report that gives only a deconvoluted mass without the charge states it was derived from cannot be checked. Deconvolution is a calculation, and a calculation whose inputs are not shown is an assertion.
| Self-association into heptamers at neutral pH means an apparently poor size exclusion result may be reversible aggregation rather than covalent dimer. The distinction requires a denaturing condition. |
| The palmitoyl chain is hydrolysable. Loss of it gives a species 238 daltons lighter that retains most of the peptide backbone. |
| Preservatives in a multi-dose formulation co-elute and must be resolved before purity is integrated. |
Every compound fails in its own way. A generic peptide method applied without regard to these specifics produces a number that looks like a result and is not one.
Long-acting GLP-1 and dual agonists carrying a fatty acid chain on a lysine side chain. The class is chemically crowded, and analogues differ by a single substitution or a linker length.
LC-MS on the multiply charged envelope with deconvolution to the neutral mass, because analogues in this class co-elute closely and a retention-time match cannot separate them. Purity by RP-HPLC at 214 nm with a shallow acetonitrile gradient.
Where the delivered milligram figure matters rather than the percentage, net peptide content by combustion analysis and water by Karl Fischer are added, and the certificate carries a closed mass balance instead of a single purity number.
| LC-MS identity | Measured mass |
| RP-HPLC purity | Area at 214 nm |
| Net peptide content | Milligrams |
| Water content | Karl Fischer |
| Counter-ion | Ion chromatography |
| Bacterial endotoxins | USP <85> |
What is the molecular weight of Liraglutide?
The average molecular weight is 3751.2 daltons and the monoisotopic mass is 3748.9465 daltons, computed from the molecular formula C172H265N43O51 shown on this page. Both figures are calculated rather than transcribed, so they can be checked against the stated composition.
How is Liraglutide tested for purity and identity?
LC-MS on the multiply charged envelope with deconvolution to the neutral mass, because analogues in this class co-elute closely and a retention-time match cannot separate them. Purity by RP-HPLC at 214 nm with a shallow acetonitrile gradient. Purity describes the chromatographable fraction only and is not the same quantity as the peptide mass delivered per vial.
What goes wrong when Liraglutide is analysed?
Self-association into heptamers at neutral pH means an apparently poor size exclusion result may be reversible aggregation rather than covalent dimer. The distinction requires a denaturing condition.
What does Liraglutide analysis cost at ANALYTON?
Blind identification, GLP-1 class is priced at 468 US dollars, covering the determinations described on this page. Content, safety and elemental determinations are ordered alongside and are priced separately on the price list.
Other compounds in this class
Updated 2026-09-01. Masses computed at build, not transcribed.